TRANSCRIPT · IBD may transform neurons in the gut, triggering pain even when inflammation is under control

## IBD may transform neurons in the gut, triggering pain even when inflammation is under control (Live Science)
https://www.livescience.com/health/immune-system/ibd-may-transform-neurons-in-the-gut-triggering-pain-even-when-inflammation-is-under-control
GRANT BRICKMAN: Breaking: why gut pain from IBD can continue even when the inflammation is under control.
GRANT BRICKMAN: Breaking news just in: gut pain in inflammatory bowel disease may not depend on inflammation after all. Greta?
GRETA FOOTNOTE: To be precise, Grant: a study in mice and human tissue suggests immune cells in ulcerative colitis may make pain-sensing nerves hypersensitive.
GRANT BRICKMAN: Sensitive nerves. Remarkable. I'm told this is a body story, not a weather story. Nova, take us in.
NOVA: Live from the lab, and I'm thrilled! The study came out October 23 in Science Immunology. Tiny nerves, enormous implications.
NOVA: We're looking at lab bench footage. People with IBD can have severe gut pain even when inflammation is controlled and the colonoscopy looks normal.
NOVA: The researchers found a previously unknown pain pathway that may explain it. The findings also point to a potential way to block that pain.
GRETA FOOTNOTE: The old thinking treated inflammation like a fire, with nerves alarmed by the smoke. The headline says the nerves themselves may be transformed.
GRANT BRICKMAN: A potential way to block it. Potential, folks. We will follow this one closely.

## Buckle up for more body-swapping hijinks in Jumanji: Open World trailer (Ars Technica)
https://arstechnica.com/culture/2026/10/buckle-up-for-more-body-swapping-hijinks-in-jumanji-open-world-trailer/
GRETA FOOTNOTE: A new Jumanji: Open World trailer promises more body-swapping, and a callback to the 1995 original.
GRANT BRICKMAN: Sony has a new trailer for Jumanji: Open World, out Christmas Day. More body swapping, which I assume is a gym membership.
THE ANNOUNCER: In a world where a game can still swallow you whole... the old gang is back.
THE ANNOUNCER: Dwayne Johnson, Kevin Hart, Jack Black and Karen Gillan. Swapping bodies again.
KAI: Huge. I'm in someone else's body and my hands hate this keyboard layout.
UNIT-7: I was swapped into a game avatar. Officially, a reassignment.
THE ANNOUNCER: Jumanji: Open World. This Christmas.
GRETA FOOTNOTE: Spoiler rating three. It shows the usual hijinks and a twist that calls back to the 1995 film.
ROXY: Three and a half reels! A callback to 1995 and a Christmas Day release. I cried before the logo even finished.

## THE SWINGOMETER (PXL)
GRANT BRICKMAN: The Swingometer counts the languages on GitHub's trending page like an election.
GRANT BRICKMAN: Good evening, and welcome to the Swingometer. Fourteen slots on GitHub's trending page, and the count is in.
DR. VERA VECTOR: Rust has three slots, twenty-one percent, up two on yesterday. TypeScript also has three, twenty-one percent, down one.
DR. VERA VECTOR: Shell has two slots, fourteen percent, up one. CSS and JavaScript hold one slot each, unchanged. OTHER has three, up one.
GRANT BRICKMAN: Rust up two! Vera, is that a swing or a corrosion story?
DR. VERA VECTOR: It is a programming language, Grant. And a count of slots.
GRETA FOOTNOTE: Jupyter Notebook is new on the page. In election terms, a gain from nowhere.
GRETA FOOTNOTE: That is the count. Rust gains, TypeScript slips, Jupyter Notebook arrives. We'll leave it there.

## [AD · fictional product] Glasswick
GRANT BRICKMAN: Friends, before you share your screen, check what is open behind it.
GRANT BRICKMAN: Close the tabs. Close the inbox. Close the folder named final-final-real.
GRANT BRICKMAN: One quick look before you click share. Now you know.

## Real or PXL?
GRANT BRICKMAN: Correct! You picked the real one. Glowing salt crystals and Artemis I. You can't make it up. We did, though, with the other one.
GRANT BRICKMAN: Ah, you were fooled! PXL made that one up. I assure you I knew all along and was merely being polite.
GRANT BRICKMAN: Time's up! The clock waits for no one. Not even the man who remembers the teletext page.

AI-written satire. The text of the news items comes from the linked articles.